KMID : 0368820050440060736
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Journal of the Korean Neuropsychiatr Association 2005 Volume.44 No. 6 p.736 ~ p.742
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Relation of Serum Homocysteine Level to Oxidative Stress in Patients with Alzheimer¡¯s Dementia.
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Cheon Jin-Sook
Lee Jang-Hyun Cho Woong Oh Byoung-Hoon
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Abstract
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Objectives: The goal of this study was to find an association between elevated blood homocysteine level in Korean patients with dementia of the Alzheimer¡¯s type (DAT), to analyze affecting factors, and to identify the role of oxidative stress which was known to be an underlying mechanism of hyperhomocysteinemia in DAT.
Methods: The subjected were consisted of 54 patients with dementia of the Alzheimer¡¯s type and 54 normal controls with age over 60. The clinical data was obtained by structured interview and medical records. Serum homocysteine, plasma total antioxidant capacity (TAC) and serum apolipoprotein E (apo E) levels were measured, and the cognitive function (Mini-Mental State Examination, MMSE), severity of dementia (Clinical Dementia Rating, CDR/Global Deterioration Scale, GDS), activities of daily living (Activities of Daily Living, ADL/Instrumental Activities of Daily Living, IADL) and severity of depression (Geriatric Depression Scale) were also evaluated using various rating scales.
Results: 1) The mean (+/-S.D.) serum homocysteine level in patients with dementia of the Alzheimer¡¯s type (21.69+/-8.24 micromol/L) was significantly (p<0.05) higher than the mean (+/-S.D.) serum homocysteine level in the control group (16.60+/-4.85 micromol/L)2) The mean age and IADL scores of DAT patients with elevated serum homocysteine level were significantly higher than those of DAT patients with normal serum homocysteine level (p<0.05). However, there were no difference between groups in the MMSE, GDS, CDR, ADL, Geriatric Depression Scale, plasma TAC and serum apo E level.3) The serum homocysteine level in patients with Alzheimer¡¯s dementia had no correlation with age, cognitive function, severity of dementia, activities of daily living, severity of depresseion nor plasma TAC and serum apo E level.
Conclusion: This study does not support the association between elevated serum homocysteine level and oxidative stress.
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KEYWORD
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Dementia of the Alzheimer¡¯s type, Homocysteine, Total antioxidant capacity, Apolipoprotein E, Oxidative stress
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